|
T22360 |
MDR-652
|
|
TRP/TRPV Channel
|
|
MDR-652 is a highly specific and efficacious agonist of nonpungent transient receptor potential vanilloid 1 (TRPV1) with Ki value of 11.4 nM and 23.8 nM for hTRPV1 and rTRPV1 respectively and EC50s for hTRPV1 and rTRPV1 ... |
|
T8975 |
PSB-SB-487
|
|
Cannabinoid Receptor
|
|
PSB-SB-487 is antagonist of GPR55. |
|
T4298 |
JNJ-47965567
|
JNJ-479655 |
P2X Receptor
|
|
JNJ-47965567 (JNJ-479655) is a selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel(with pKis of 7.9 and 8.7 for human and rat P2X7, respectively). |
|
T16164 |
MY-5445
|
N-(3-chlorophenyl)-4-phenylphthalazin-1-amine |
PDE
|
|
MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) is a specific inhibitor of phosphodiesterase type 5 (PDE5). MY-5445 selectively inhibits cGMP PDE (Ki:1.3 μM). |
|
TQ0002 |
A-317491
|
ABT 202 |
P2X Receptor
|
|
A-317491 (ABT 202) is a non-nucleotide P2X3 ( Ki: 22 nM) and P2X2/3 receptor (Ki: 9 nM) antagonist, which inhibits calcium flux mediated by the receptors. |
|
T16014 |
Mavatrep
|
JNJ-39439335 |
TRP/TRPV Channel
|
|
Mavatrep (JNJ-39439335) is a selective antagonist of TRPV1 with Ki of 6.5 nM and can be used for studies about inflammatory pain. |
|
T0386L |
Ropivacaine
|
LEA-103 HCl |
Potassium Channel
,
Sodium Channel
|
|
Ropivacaine (LEA-103 HCl) is a local anaesthetic drug belonging to the amino amide group. |
|
T7748 |
Dermorphin TFA
|
|
Others
,
Opioid Receptor
|
|
Dermorphin TFA is a new class of opioids-like peptides |
|
T21980 |
PD 198306
|
|
MEK
|
|
PD 198306 is a selective inhibitor of MAPK/ERK-kinase (MEK) with antihyperalgesic effects. PD 198306 reduces the Streptozocin-induced increase in the level of active ERK1. |
|
T7416 |
WS-12
|
|
TRP/TRPV Channel
|
|
WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 : 193 nM) |
|
T0386 |
Ropivacaine hydrochloride
|
Ropivacaine monohydrochloride |
Potassium Channel
,
Sodium Channel
|
|
Ropivacaine hydrochloride (Ropivacaine monohydrochloride) is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity. |
|
T23008L |
MMPIP hydrochloride
|
MMPIP hydrochloride (479077-02-6 Free base) |
GluR
|
|
MMPIP hydrochloride is a selective antagonist of allosteric mGluR7. MMPIP hydrochloride can be used in research on the roles of mGluR7 on central nervous system functions. |
|
T8579 |
Nav1.8-IN-1
|
5-(4-Chlorophenyl)-N-[[2-(2,2,2-trifluoroethoxy)pyridin-3-yl]methyl]pyridine-3-carboxamide,CHEMBL1270208 |
Sodium Channel
|
|
Nav1.8-IN-1 (CHEMBL1270208) is an inhibitor of human NaV1.8 |
|
T8333 |
Aurintricarboxylic acid
|
ATA,NSC-4056,NSC4056,NSC 4056 |
Apoptosis
,
P2X Receptor
,
Influenza Virus
,
Topoisomerase
|
|
Aurintricarboxylic acid (NSC-4056) is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. |
|
T7705 |
GW 405833
|
L-768242 |
Cannabinoid Receptor
|
|
GW 405833 (L-768242) is an agonist of cannabinoid-2 (CB(2)) receptor-selective |
|
T29112 |
VPC171
|
VPC 171,VPC-171 |
Adenosine Receptor
|
|
VPC171 is a novel adenosine A1 receptor positive allosteric modulator (PAM). |
|
T3280 |
Clodronate disodium tetrahydrate
|
clodronic acid disodium tetrahydrate,Disodium clodronate tetrahydrate,Clastoban,Clodronate disodium |
IL Receptor
,
TNF
|
|
Clodronate disodium tetrahydrate (Clastoban) inhibits bone resorption and soft tissue calcification. |
|
T0678 |
Amitriptyline hydrochloride
|
Amitriptyline HCl,Tryptizol,Domical,Annoyltin |
Trk receptor
,
Sigma receptor
,
5-HT Receptor
,
Serotonin Transporter
,
Sodium Channel
,
Adrenergic Receptor
,
AChR
,
Norepinephrine
,
Histamine Receptor
|
|
Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities. |
|
T6645 |
Ropivacaine hydrochloride monohydrate
|
Ropivacaine HCl,Ropivacaine HCl monohydrate,LEA 103,LEA-103 HCl |
Potassium Channel
,
Sodium Channel
|
|
Ropivacaine hydrochloride monohydrate (LEA-103 HCl) is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly. |
|
T7404 |
Dermorphin
|
|
Opioid Receptor
|
|
Dermorphin is agonist of μ-opioid receptor (MOR) agonist. |
|
T27178 |
Dimiracetam
|
ISF4185,ISF-4185,NT11624,NT-11624,BND11624,BND-11624 |
|
|
Dimiracetam, a NMDA-receptor antagonist, is used potentially for the treatment of neuropathic pain. |
|
T28059 |
MK-4409
|
MK4409,MK 4409 |
|
|
MK-4409, a potent and selective fatty acid amide hydrolase (FAAH) inhibitor, is being investigated for the treatment of inflammatory and neuropathic pain. |
|
T16514 |
PF 04531083
|
|
Others
,
Sodium Channel
|
|
PF 04531083 is a selective blocker of the NaV1.8 channel. PF 04531083 can be used for neuropathic and inflammatory pain studies. |
|
T6507 |
Gabapentin hydrochloride
|
Neurontin HCl,Gabapentin HCl |
Calcium Channel
,
GABA Receptor
|
|
Gabapentin hydrochloride (Neurontin HCl) is a GABA analogue, used to treat seizures and neuropathic pain. |
|
T12910 |
Sigma-1 receptor antagonist 1
|
|
Sigma receptor
|
|
Sigma-1 receptor antagonist 1 is an effective and selective antagonist of sigma-1 receptor. Sigma-1 receptor antagonist 1 exhibits antineuropathic pain activity and can be used in the treatment of neuropathic pain studie... |
|
T31208 |
Dasolampanel
|
NGX-426,NGX 426,NGX426 |
GluR
,
iGluR
|
|
Dasolampanel (NGX-426) is an orally available ionotropic glutamate receptor AMPA and Kainate receptor antagonist for the study of chronic pain disorders, including neuropathic pain and migraine. |
|
T7349 |
Ralfinamide
|
Priralfinamide,FCE-26742A |
Sodium Channel
|
|
Ralfinamide (Priralfinamide) is an orally available Na-channel blocker for the treatment of neuropathic pain and other pain conditions. |
|
T34308 |
Rezatomidine
|
AGN-203818,AGN203818,AGN 203818 |
Adrenergic Receptor
|
|
Rezatomidine (AGN203818) is a selective antagonist of α2-adrenergic receptor and can be used in studies about chronic pain, including neuropathic pain. |
|
T22240 |
Amitriptyline
|
|
Sigma receptor
,
5-HT Receptor
,
Norepinephrine
,
Histamine Receptor
|
|
Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties. Amitriptyline is widely used to treat depression and neuropathic pain. |
|
T11724 |
JNJ-42226314
|
|
Lipase
|
|
JNJ-42226314 is a highly selective non-covalent monoacylglycerol lipase (MAGL) inhibitor with anti-injury effects.JNJ-42226314 shows efficacy via endogenous cannabinoid-2-acryloylglycerol (2-AG) in models of neuropathic ... |
|
T0598 |
Iminostilbene
|
Dibenzazepine |
Others
|
|
Iminostilbene (Dibenzazepine) (Dibenzazepine) is a chemical precursor of carbamazepine which is used primarily in the treatment of epilepsy and neuropathic pain. |
|
T27404 |
GAT107
|
GAT 107,GAT-107 |
AChR
|
|
GAT107 is a novel and potent α7 nicotinic cholinergic receptor modifier agonist and modulator with anti-inflammatory activity that reverses injury perception in a mouse model of neuropathic pain. |
|
T10190 |
7-BIA
|
|
Phosphatase
|
|
|
|
T20494L |
Acetyl tetrapeptide-15 Acetate
|
Skinasensyl Acetate,Acetyl tetrapeptide-15 Acetate (928007-64-1 Free base) |
|
|
Acetyl tetrapeptide-15 Acetate (Skinasensyl Acetate), a synthetic peptide used in cosmetic products for sensitive skin, is an endomorphin-2 derivative that extends the range of neuronal excitability thresholds in the μ-o... |
|
T77606 |
WAY-311610
|
|
Dehydrogenase
|
|
WAY-311610 is an 11β-hydroxysteroid dehydrogenase HSD11B1 inhibitor that inhibits the 11β-HSD1 enzyme with an IC = 0.34 μM.It can be used to study neuropathic pain, inflammatory pain, and occipital neuralgia. |
|
T79500L |
KSK94 FA
|
KSK94 FA(2566716-07-0 Free base) |
Histamine Receptor
|
|
KSK94 FA is a potent histamine H3 receptor antagonist that inhibits H3 receptors and is used in the study of neuropathic pain and obesity. |
|
T5698 |
TRPM8 antagonist 2
|
|
TRP/TRPV Channel
|
|
TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist with an IC50 of 0.2 nM. TRPM8 antagonist 2 is used in the research of neuropathic pain syndromes. |
|
T77333L |
(Iso)-BMT-124110 Formate
|
(R)-N-(8-((2-amino-2,4-dimethylpentyl)oxy)-5H-chromeno[3,4-c]pyridin-2-yl)acetamide Formate（1679370-98-9 Free base） |
AAK1 (AP2 associated kinase 1)
|
|
(Iso)-BMT-124110 Formate has an inhibitory effect on the protein serine/threonine kinase AAK, and is used in the treatment of Parkinson's disease, schizophrenia, neuropathic pain, and Alzheimer's disease. |
|
T3699 |
Bay 59-3074
|
|
Cannabinoid Receptor
|
|
Bay 59-3074 is a CB1/CB2 receptor partial agonist (Ki: 48.3/45.5 nM). In rat models of chronic neuropathic and inflammatory pain, it displays anti-hyperalgesic and antiallodynic properties. |
|
T5385 |
Radiprodil
|
RGH-896 |
NMDAR
,
iGluR
|
|
Radiprodil (RGH-896) (RGH-896) is an orally active and selective NMDA NR2B receptors antagonist. It was a potential treatment of neuropathic pain associated with diabetic peripheral neuropathy (DPNP). |
|
T79500 |
KSK94
|
|
Histamine Receptor
|
|
KSK94 is a specific H3 receptor antagonist that inhibits H3, sigma-1, and sigma-2 receptors , with Ki values of 7.9, 2958, and 75.2 nM, respectively, and can be used to study injurious pain and neuropathic pain. |
|
T1109 |
(Z)-Capsaicin
|
Zucapsaicin,Civamide,cis-Capsaicin |
TRP/TRPV Channel
,
HSV
|
|
(Z)-Capsaicin (Zucapsaicin) is a medication used to treat osteoarthritis of the knee and Others neuropathic pain.(Z)-Capsaicin is a synthetic cis isomer of natural capsaicin that has shown therapeutic efficacy in pain ac... |
|
T77593 |
KSK67
|
|
Sigma receptor
|
|
KSK67 is a selective dual antagonist of sigma-2 and histamine H3 receptors with inhibitory effects on H3 receptors, sigma-1, and sigma-2 receptors, with Ki values of 3.2, 1531, and 101 nM, respectively.KSK67 can be used ... |
|
T9955 |
EX-A5758
|
|
NOS
|
|
EX-A5758 is a novel putative small molecule nNOS-NOS1AP inhibitor, suppressing inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability. |
|
T12051 |
MIV-247
|
|
Cysteine Protease
|
|
MIV-247 is a selective and potent inhibitor of cathepsin S (Kis 2.1, 4.2, and 7.5 nM for human, mouse, and wild monkey cathepsin S, respectively), which attenuates mechanical anomalies in preclinical models of neuropathi... |
|
T3690 |
A-740003
|
A 740003 |
P2X Receptor
|
|
A-740003 (A 740003) is an effective and specific P2X7 receptor antagonist (IC50: 18/40 nM, for rat/human). It can reduce nociception in animal models of persistent neuropathic and inflammatory pain, and also reduce neuro... |
|
T37427 |
(2R/S)-6-PNG
|
6-Prenylnaringenin,(±)-6-Prenylnaringenin |
Calcium Channel
,
HDAC
|
|
(2R/S)-6-PNG (6-Prenylnaringenin) is a novel natural histone deacetylase inhibitor with anticancer and antitumor activity, and blocks T-type calcium channels to reduce neuropathic and visceral pain in mice. |
|
TP1559L |
Ziconotide Acetate (107452-89-1 free base)
|
Prialt,Ziconotide Acetate |
Calcium Channel
|
|
Ziconotide Acetate (107452-89-1 free base) (Prialt) is an analgesic agent and has been used to treat neuropathic and non-neuropathic pain. Ziconotide Acetate (107452-89-1 free base) acts by binding to N-type calcium chan... |
|
T5815 |
MJN110
|
Cravatt Reagent |
Lipase
|
|
MJN110 (Cravatt Reagent) is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110(Cravatt Reagent) Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model. |
|
TP1933 |
R715 TFA(185052-09-9 free base)
|
R 715 |
Bradykinin Receptor
|
|
R715 TFA(185052-09-9 free base) is a potent and selective bradykinin B1 receptor antagonist (pA2 = 8.49). Displays no activity at B2 receptors. Reduces mechanical hypernociception in a mouse model of neuropathic pain. Me... |
